In the first quarter of 2024, Bio-Rad Laboratories, Inc. (NYSE: NYSE:BIO) reported a decrease in net sales, recording $611 million, which is a 9.8% decline compared to the same period in 2023.
Despite this downturn, the company's Clinical Diagnostics group displayed solid growth, and the gross margin remained stable at 53.4%. Bio-Rad expressed a cautious yet optimistic view for the recovery of the life science markets, anticipating improvements in the latter half of the year.
The company's financial health appears resilient, with an increase in net income and diluted earnings per share, attributed to the valuation of Sartorius holdings. Bio-Rad has welcomed Roop Lakkaraju as the new CFO and is actively progressing in filling key positions.
The company has reaffirmed its full-year outlook, expecting revenue growth between 1% and 2.5%, and a non-GAAP operating margin between 13.5% and 14%.
Key Takeaways
- Net sales declined by 9.8% year-over-year to $611 million in Q1 2024.
- Gross margin remained consistent at 53.4% despite sales decline.
- Clinical Diagnostics group showed growth; Life Science group faced market challenges.
- Operating income decreased due to lower sales but was partially offset by cost management.
- Net income and diluted EPS increased, benefiting from the valuation of Sartorius holdings.
- Full-year revenue growth is projected to be between 1% and 2.5%.
- Non-GAAP operating margin is expected to remain between 13.5% and 14%.
Company Outlook
- Bio-Rad expects improvements in life science markets in the second half of the year.
- The company remains focused on long-term growth, particularly in the biopharma market segment.
- Digital PCR franchise is performing well and is expected to recover alongside market conditions.
- Executives are optimistic about capital influx into biotech and biopharmaceuticals but await this to translate into orders.
- Gross margin is anticipated to stay strong for the full year.
Bearish Highlights
- Sales in the Life Science group declined due to weaker performance in key markets.
- The company has not yet seen the increased capital in biotech and biopharmaceuticals reflected in orders.
Bullish Highlights
- The Clinical Diagnostics group demonstrated growth.
- The company has successfully reduced costs, which helped maintain a steady gross margin.
- Bio-Rad is entering a new market segment later this year, which could present additional growth opportunities.
Misses
- First-quarter sales fell short of the previous year's figures.
- Non-GAAP operating margin decreased compared to the same period in 2023.
Q&A Highlights
- Employee retention remains stable following management changes.
- Partnerships with Allegheny, onco site, and genoscopy are expected to yield long-term benefits, though not immediately impacting revenue.
- Upcoming healthcare conferences are seen as opportunities to engage with investors and stakeholders.
Bio-Rad's earnings call revealed a company navigating through market challenges with a strategic focus on cost management and long-term growth. The firm's ability to maintain gross margins in the face of declining sales suggests a robust operational framework.
As Bio-Rad prepares to enter new market segments and capitalizes on its partnerships, the company's outlook remains cautiously positive, banking on a stronger second half of the year to meet its full-year guidance.
InvestingPro Insights
In light of Bio-Rad Laboratories' recent financial performance, several metrics and tips from InvestingPro provide a deeper understanding of the company's position and potential. As of the last twelve months ending Q4 2023, Bio-Rad has a market capitalization of approximately $7.98 billion, with a Price/Earnings (P/E) ratio of -12.85, indicating that the market currently does not expect earnings to justify the stock price. However, the adjusted P/E ratio for the same period stands at 22.94, which may suggest a more favorable view of the company's future earnings potential.
InvestingPro Tips suggest that management has been actively buying back shares, which could be a sign of confidence in the company's value. Furthermore, analysts expect net income to grow this year, which aligns with the company's cautious optimism about improvements in the life science markets during the second half of the year.
From a financial health perspective, Bio-Rad's liquid assets exceed its short-term obligations, providing a cushion for the company in managing its cash flow and potential investments. This is particularly relevant as the company focuses on long-term growth and entering new market segments.
InvestingPro Data highlights that Bio-Rad's revenue for the last twelve months as of Q4 2023 was $2.67 billion, with a gross profit margin of 53.56%, closely reflecting the stable gross margin reported in Q1 2024. Despite the recent decline in net sales, the company's gross profit margin remains a strong point.
For those looking to delve deeper into Bio-Rad's financials and future prospects, InvestingPro offers additional tips to guide investment decisions. With the use of the coupon code PRONEWS24, readers can get an additional 10% off a yearly or biyearly Pro and Pro+ subscription, gaining access to a wealth of insights and analysis. There are 11 additional InvestingPro Tips available at https://www.investing.com/pro/BIO, which can further inform investors about Bio-Rad's strategic moves and market positioning.
Full transcript - Bio-Rad Laboratories Inc (BIO) Q1 2024:
Operator: Good afternoon everyone, and welcome to today's Bio-Rad First Quarter 2024 Earnings Results Conference Call. At this time, all lines are in a listen-only mode. Later, you will have the opportunity to ask questions during the question and answer session. [Operator Instructions] And now at this time, I'll turn things over to Mister Edward Chung, head of investor relations. Please go ahead, Mister Chung.
Edward Chung: Thanks, Jenny. Good afternoon, everyone, and thank you for joining us. Today, we will review the first quarter 2024 financial results and provide an update on key business trends for Bio-Rad. With me on the call today are Norman Schwartz, our Chief Executive Officer; Andy Last, Executive Vice President and Chief Operating Officer; and Simon May, President of the Life Science Group. Before we begin our review, I would like to caution everyone that we will be making forward-looking statements about management’s goals, plans and expectations, our future financial performance and other matters. These statements are based on assumptions and expectations of future events that are subject to risks and uncertainties. Our actual results may differ materially from these plans, goals and expectations. You should not place undue reliance on these forward-looking statements and I encourage you to review our filings with the SEC where we discuss in detail the risk factors in our business. The company does not intend to update any forward-looking statements made during the call today. Finally, our remarks today will include references to non-GAAP financials, including net income and diluted earnings per share, which are financial measures that are not defined under Generally Accepted Accounting Principles. Investors should review the reconciliation of these non-GAAP measures to the comparable GAAP results contained in our earnings release. With that, I'll now turn the call over to our CEO, Norman Schwartz.
Norman Schwartz: Thanks Ed. First, what I want to do is officially welcome and introduce Roop Lakkaraju, our new CFO. He comes to us with a wealth of financial and operational experience, which will certainly be valuable as we move forward. Roop has now been on-board about four weeks and already contributing. In fact, Roop will walk you through our financial results for the first quarter in a few minutes, but I just want to say a few words. We have received questions about management turnover and succession in the last six months. I thought it would be useful to say a few words. So, in short, as I think about it, each of these discrete departures is really centered around personal decisions either related to other opportunities or, or retirement. From my perspective, it's all part of a normal progression for these individuals and for the company. And of course, with all of these individuals, I just want to take a minute to recognize and thank them for their contributions. So as we move forward, we are making good progress filling some of these open positions. Some positions are being filled with external candidates like Roop, which gives the company an opportunity to bring in fresh outside experience and perspective. And others are being filled with internal candidates like Jim Berry, who we've recently announced as our new Head of Life Science. Jim brings a deep understanding of the company, along with significant expertise in a variety of areas. So as I think about it today, with Roop on board, the finance team is fully staffed and we're close to an announcement on the new head of diagnostics. In addition, we have good initial candidate pool for the COO position. I do feel these changes as opportunities to bring fresh insights and ideas to the table as we continue our transformational journey. So with that, maybe I'll turn the call over to Andy to provide an update on Bio Rad's global operations. Andy?
Andy Last: Okay, thank you Norman good afternoon everybody. Thank you for joining us. The first quarter of 2024 reflected a continuation of the same macroeconomic and market trends we had experienced in 2023 in the biotech and bio-pharma segments, as well as China and Russia. As a result, our life science group was in line with expectations and presented a soft quarter sales with a year over year decline, which also reflected a tough comparison from Q1 of '23. In contrast, we were pleased with our clinical diagnostics group, which showed growth across all regions and provided a solid offsetting balance for overall bio-ad sales. Our life science business experienced double digit declines both across our core and bioprocessing product families. As previously communicated, our process chromatography sales, which have quarter-to-quarter lumpiness, were down significantly against a tough compare in Q1 2023. This reflects the general destocking trend across the industry and for us is the result of a few large customers still working through excess inventory. While we have seen indications of some customers starting to forecast purchase improvements, overall we are expecting a further decline for process chromatography sales this year. However, we have converted some early customers from competing resins to our platform during the first quarter and have not lost any customers. As such, we remain positive on the long term growth potential for this business. Overall, our core life science business, excluding process chromatography resins, declined in the mid teens in all regions, which was in line with expectations notably, declines were concentrated in instrument sales, whereas consumable and reagent sales were essentially flat both sequentially and year over year. We are also looking forward to new product launches this year, more particularly the new ChemiDoc go platform and our new single cell sample prep solution in Q2 and of course the QX continuum later in the year, all of which are contemplated on our outlook for the year. Our droplet digital PCR franchise was soft in Q1, again with a tough Q1 2023 compare, but the decline was single digit compared to our overall core life science sales during the quarter. We continued to make progress on our strategy and we announced two deals in support of driving penetration of the platform into advanced clinical diagnostic use. The first, with Allegheny Health Network, is focused on generating clinical evidence across a range of cancer types using Bio Rad's droplet digital PCR technology for tumour informed minimal residual disease monitoring of patients with solid tumour cancer following treatment. The second agreement is a collaboration with oncocytes to commercialize their advanced transplant monitoring assays, deploying Bio-Rads Qx 600 droplet digital PCR system to provide a highly sensitive solution that could provide a more attractive alternative for laboratories that currently rely on centralized next generation sequencing test providers. During Q1, we also released a new multiplex mutation detection assay providing a comprehensive status readout of mutations in ESR one, which is a key gene in breast cancer. We are very excited by the initial response we have seen for this assay. We are also pleased to see a key partner genoscopy announcing FDA approval of colosense, their new non invasive RNA based colorectal cancer screening test that runs on our digital PCR platform. Moving on to our clinical diagnostics business, we were very pleased with the broad based performance of our products in Q1 as we saw solid mid single digit growth compared to a softer Q1 2023 with particular strength in EMEA and Asia Pacific. Strong sales and quality controls, immunohematology and diabetes were of note and instrument supply for our clinical platform is now stabilized as we benefit from our new manufacturing facility in Singapore, which is fully operational. Reflecting on the first quarter's macroeconomic and market conditions, they broadly matched our expectations. We were pleased to see the positive trend for capital raises flowing into the biotech and biopharma markets, which is a prerequisite for second half growth, although we have not yet seen any signs of the funding making its way into orders and expect this to be a second half of the year. Impact China remains soft for the life science business although the Chinese government stimulus announcement was encouraging for the longer term recovery of the market. We also continue to navigate the sanctions imposed on Russia, where we maintain supply of some critical clinical diagnostic products. In the US, finalization of the NIH budget was delayed until late March and at a slightly lower level than anticipated and in the key European markets, government funding was more of a mixed bag, with Germany down and generally flat in the UK and France. With this backdrop in mind, we remain cautious on the magnitude and timing of the recovery in life science markets, but are still anticipating improvements in the second half. We continue to expect normalized growth for our clinical diagnostics business in 2024. With that, I'll say thank you and I'll now pass you to Roop to review the financial results
Roop Lakkaraju: Thank you Andy. I'd now like to review the results for the first quarter net sales for the first quarter of 2024 $611 million, which is a 9.8% decline on a reported basis versus $677 million in Q1 of 2023 on a currency neutral basis. The year over year revenue decline was 9.6%. As Andy mentioned, the year over year decline was primarily the result of ongoing weakness in key life science end markets, somewhat offset by steady growth of the clinical diagnostics group. Sales of the life Science group in the first quarter of 2024 were $242 million compared to $324 million in Q1 of 2023, which is a decrease of 25.3% on a reported basis and a decline of 25.2% on a currency neutral basis. The year over year decline impacted most product and geographic areas, excluding process chromatography sales, which can fluctuate quarter-to-quarter. Life Science group revenue decreased 16.6% on a currency neutral basis. Sales of the clinical diagnostics group in the first quarter were $369 million compared to $352 million in Q1 of 2023, which is an increase of 4.7% on a reported basis and 4.8% on a currency neutral basis. Growth of the clinical diagnostics group was primarily driven by increased demand for quality controls, blood typing and diabetes on a geographic basis. Currency neutral year over year revenue for the diagnostics group posted balanced growth across all three regions for the company. Q1 reported GAAP gross margin of 53.4% as compared to 53.5% in the first quarter of 2023 was in line with our expectations as we maintained a tight focus on manufacturing costs, which was partially offset by higher material cost and lower absorption. Amortization related to prior acquisitions recorded in cost of goods sold was approximately $4 million in both periods. SG&A expenses for Q1 2024 were $215 million, or 35.2% of sales compared to $226 million, or 33% in Q1 of 2023. The decrease in SG&A spend was driven by the positive impact of our previously discussed cost reduction initiatives, including lower employee related expenses and discretionary spend as well as higher restructuring charges in the year ago period. Total amortization expense related to acquisitions recorded in SG&A for the quarter was approximately $1 million for versus approximately $2 million in Q1 of 2023. Research and development expense in the first quarter was $66 million, or 10.9% of sales compared to $75 million, or 11.1% of sales in Q1 of 2023. Year-over-year decrease was primarily due to decreased employee related expenses and lower restructuring costs. Q1 operating income was $45 million, or 7.3% of sales compared to $62 million, or 9.1% of sales in Q1 of 2023, primarily due to lower sales versus the year ago period, which were partially offset by our expense management initiatives. Looking below the operating line, the change in fair market value of equity security holdings, which are substantially related to Bio-Rad's ownership of Sartorius AG shares, added $422 million of income to the reported results during the quarter. Interest and other income resulted in net other income of $24 million compared to net other income of $40 million last year. The primary driver of the year over year change is the lower Sartorius dividend, which declined to $18 million in Q1 of 2024 versus the quarter of 2023. The effective tax rate for the first quarter of 2024 was 21.8% compared to 18.7% the same period in 2023. The effective tax rate reported in these periods was primarily affected by the accounting treatment of our equity securities. First quarter reported net income was $384 million or $13.45 diluted earnings per share compared to net income of $69 million, or a diluted earnings per share of $2.32 in Q1 of 2023. This change from last year is largely related to changes in the valuation of our Sartorius holdings. Moving on to the non-GAAP results looking at the results on a non-GAAP basis, we have excluded certain atypical and unique items that impacted both the gross and operating margins as well as other income. These items are detailed in the reconciliation table in the press release. Looking at the non-GAAP results for the first quarter in cost of goods sold, we have excluded approximately $4 million of amortization of purchased intangibles and approximately $1 million of restructuring expense. These exclusions moved the non-GAAP gross margin to 54.2% for the first quarter of 2024, which is flat to Q1 of 2023 non-GAAP SG&A dollar spend was slightly lower on a year over year basis, but as a percentage of sales was higher due to lower revenue in Q 124. Specifically, in the first quarter of 24, SG&A as a percent was 34% versus 31.3% in Q1 of 2023 in SG&A on a non-GAAP basis, we have excluded amortization of intangibles of approximately $1 million, approximately $2 billion for an in vitro diagnostic registration fee in Europe for previously approved products and approximately $4 million of restructuring related expenses. Non-GAAP SG&A as a percentage of sales in the first quarter of 2024 was 10.5% versus 10.4% in Q1 of 2023 in R&D. On a non-GAAP basis, we have excluded approximately $2 million of restructuring expenses and a small acquisition expense. The cumulative sum of these non-GAAP adjustments result in moving the quarterly operating margin from 7.3% on a GAAP basis to 9.7% on a non-GAAP basis. This non-GAAP operating margin compares to non-GAAP operating margin of 12.4% in Q1 of 2023. We've also excluded certain items below the operating line, which is primarily related to the increase in value of the Sartorius equity securities and loan receivable holdings of $422 million. The non-GAAP effective tax rate for the first quarter of 2024 was 22.3% compared to 20.9% for the same period in 2023. A higher rate in 2024 was driven by geographical mix of earnings and change in valuation allowance related to our deferred tax assets. Finally, non-GAAP net income for the first quarter of 2024 was $65 million, or $2.29 diluted earnings per share compared to $99 million, or a diluted earnings per share, $3.34in Q1 of 2023. Moving on to the balance sheet, total cash and short term investments at the end of Q1 2024 was $1,651,000,000 compared to $1,613,000,000 at the end of 2023. The change in cash and short term investments from the fourth quarter of 2023 was primarily due to the change in working capital. Inventory of $783 million was essentially flat compared to $781 million in the prior quarter. For the first quarter of 2024, net cash generated from operating activities was $70 million, which compares to $98 million in Q1 of 2023. Net capital expenditures for the first quarter of 2024 were $40 million and depreciation and amortization was $37 million. Adjusted EBITDA for the first quarter of 2024, $109 million, or 17.8% of sales and excluding the Sartorius dividend, was 14.8%. The adjusted EBITDA for the first quarter of 2023 was $149 million, or 21.9% of sales and excluding the Sartorius dividend, was 16.8%. During the first quarter, we purchased 14,250 shares of our stock for a total cost of approximately $5 million, or an average purchase price of approximately $330 per share. We continue to be opportunistic with our buyback program and still have approximately $275 million available for share repurchases under the current board authorized program. Moving on to the non-GAAP guidance as referenced in Andy's commentary, we are seeing some encouraging signs in life science end markets. However, we remain cautious on the magnitude and timing of the recovery for the life Science group, but are still anticipating improvement during the second half of the year. We continue to expect normalized growth for the clinical diagnostics group in 2024. Taken together, we are maintaining our full year outlook with currency neutral revenue growth to to be between one and 2.5% and non-GAAP operating margin projected to be between 13.5% and 14%. I'll now hand the call back to Norman to make a few concluding remarks.
Norman Schwartz: Thanks Roop. Just to close it out, I'd like to reiterate that in spite of all that's going on around us, our strategy and our focus for the future growth of the company is intact. In our clinical diagnostics business, we have these leading market positions globally for our core platforms and we continue to invest in supporting the growth and building a position in, for example, the new molecular diagnostic segments through the development of PCR one, an acquisition we made some time ago, and leveraging our droplet digital PCR platform into high value niches in life science, we continue to maintain a focus on biopharma, especially for digital PCR. Our process chromatography products and new products in development say particularly around cell biology. We do believe the long term opportunity for sustained growth in this biopharma market segment is solid, and certainly we also continue to invest to enhance our leadership in digital PCR and other leading platform positions in the academic markets that we serve. Overall, between life science and diagnostics, we do believe we're well positioned to drive long term growth as we move through this dynamic period. All right, that concludes our prepared remarks, and we will now open the line to take your questions. Operator?
Operator: Thank you, gentlemen. [Operator instructions]. We go first this afternoon to Patrick Donnelly of Citi.
Patrick Donnelly: Hey, guys, thanks for taking the questions. Maybe start on the life science business. I came in a little bit, a little bit light of what we were looking for. Can you talk about. It seems like process Chrome is an area you're calling out with a little bit of softness. Can you talk about what you saw in the quarter and then obviously maintaining the full year guide? Can you talk about the expectations for the life science business as we work our way through the year here? Growth expectations for the year at that segment?
Andy Last: Hi, Patrick. It's Andy. So let me take that question. So, first on process chromatography in the quarter, you know, I mean big a tough compare to 2023 for sure. I think the core life science business kind of really met expectations. So we did call out that, I think for us, process chromatography is softer than we anticipated, and that kind of drove the delta for us as we look forward to the rest of the year. At this point in time, we're considering that process Chrome is going to be softer than originally anticipated. I just want to reiterate, because it's a valid question, we're not seeing that we're losing customers. We're maintaining share. In fact, we still believe we are winning share, as we called out on the script on life science. It's just a higher level of uncertainty, I think, is where we sit right now. And most of the, if not virtually all of the delta in life sciences instrument, the consumables and reagents, are actually performing pretty consistently, sequentially and year-over-year. So it's kind of. It's the spend on capital spend on equipment, which is the major delta for us right now.
Patrick Donnelly: Okay. So I guess when you think about maintaining a guide for the year overall, you know, process chrome softened a bit. Are there offsets that came in better than you expected that are now you're thinking a little bit higher growth for the year? I'm just trying to figure out the balance here and the visibility into.
Andy Last: Yes, so I think the core life sciences, you know, with the caveats that I just mentioned, I think is in-line. There's some strength in clinical diagnostics that looks good to us right now, which kind of keeps us within our guide range overall.
Patrick Donnelly: Okay. And then maybe just on ddPCR, how did that perform in the quarter? How are you seeing the competitive landscape there? How did things trend and expectations for the year on that front as well would be helpful.
Andy Last: Yes. So interestingly, relative to core life science, which was down mid teens, the digital PCR franchise was down single digit percentage, and it was all concentrated in instruments. The consumable reagent pull through was pretty good. And as we look forward, we view the franchise recovering in line with market recovery as we go, as we go through the remaining quarters in the year competitively, we're not seeing any change to our win loss ratio. And of course, our major competition is calling out some improvement in their year over year performance. It's not lost on us, but we just want to reiterate that they're in a segment which we've not yet entered, which we'll be entering later this year.
Operator: We go next now to Dan Leonard of UBS.
Selena Lu: Great. This is Lu on for Dan. Thank you for taking my questions. I think the first question wanted to touch a little bit on the life sciences as well. Can you share a little bit more color in the order trends and maybe also the funnel activities I think you mentioned about funding improvement. Have you seen any increasing activities from your customers?
Andy Last: Yes. So thank you for the question, It's Andy, again. So I think where we sit right now, really encouraged by the influx of capital into biotech biopharmaceutical, that really is a pre-requisite to second half growth. It's not showed up in Ayurveda books as yet. And the funnel is, we're starting to have more positive sentiment and conversations within that segment, but it's not showed up yet as hard and fast orders.
Selena Lu: Got it. Appreciated. So I guess I probably wanted to touch on a little bit on the guidance as well. So it does look that the second half, the ramp is a lot steeper, both in the revenue and margin. And then also, you just mentioned you haven't seen anything in the orders yet, so can you just maybe share a little bit in terms of the visibility and your confidence in maintaining the guidelines and then also maybe how we should think about q two as well? Do you see improving signals in April so could help you to see the sequential improvement? Yes, I think I'd kind of answer that question as a carry on from my previous answer as it relates to biotech biopharma?
Andy Last: You know, I do think that we need to, we need to see the kind of encouraging signs turn into waters for the second half, which obviously will generate the ramp process. Chromatography we view as being, you know, really a more challenging year overall due to destocking. But we see some, you know, good growth in our clinical diagnostics business. And, you know, we envisage that continuing throughout the year. So I think really just a reconfirmation of the comments that we made in the script and my earlier answer.
Selena Lu: Got it. Just final questions on the gross margin. It does come better than what we expected, given the lower volume. Can you share a little bit the drivers of that? And then what's your expectation for the full year?
Roop Lakkaraju: Yes. Hi, this is Roop. I'll take this to start. First of all, it did come in a little bit stronger, which we were very happy about, and part of it was expected just based on the cost actions we've taken and these sort of things. But also what played a part is the mix. And so that helps support a little bit of a stronger gross margin there. I think, as we think about the rest of the year, and as Andy pointed out, we feel good about the overall view for the full year on the gross margin. Based on mix and quarter-to-quarter movement, we may see a slight movement in that gross margin, but overall for the full year, we still feel very confident as it relates to how it fits in with our overall outlook for the year.
Operator: We'll go next now to Jack Meehan with Nephron research.
Jack Meehan: Thank you. Good afternoon. First question is for Norman. I was just wondering if you give a little bit more color on when we should expect updates in terms of the management hires for the new COO and also the plan for the new head of diagnostics.
Norman Schwartz: Yes, I think we're getting pretty close on the, on the diagnostics higher. I think we'll have something to announce pretty soon. And, you know, we've got a really good pool of candidates on the COO side that'll probably take a little longer, but we're pretty encouraged.
Jack Meehan: Great. And then for Roop, first, welcome to Bio Rad and had a couple of questions for you. The first is, could you just talk about, as you're new in the seat, how you went about sizing up the guidance for 2024? And second is if you just talk about the cadence you're expecting for margins starting from 9.7 to get to the full year target, how you feel like that phases throughout the year and how you got confidence in that.
Roop Lakkaraju: Sure. So, first of all, thank you for the welcome. In terms of the process on the guidance, first of all, the company has an existing process, business review cadence that was already in existence. And so part of this was really for me to seamlessly integrate into the existing processes as part of those processes. We start out with looking at revenue on a quarterly basis, quarterly basis with our sales teams and walking through revenue drivers and market conditions and these sort of things, and then profiling that against what we were expecting and understanding how mix might affect the next piece, which is the margins and these sort of things. There's also a number of cost actions that have been taken historically that we were also monitoring the impact of those cost actions, as well as kind of market dynamics around materials, pricing, logistics trends, these sort of things, and how that might affect the margin profile. So we then just kind of walk down through the different areas of the P&L. When we got to the opex, it really is more around a run rate, the effect of things like merit and how that plays through. So we walked through that analytically and then getting down, obviously to the operating income based on the different drivers and our expectations and feedback from our sales team on how the ramp might look, how then that might flow through the factory. From an absorption standpoint, it gave us confidence on reiterating our guidance overall. And also, just to finish off the thought, I think, to your phasing conversation question, that also gave us perspective on how to think about the quarter-to-quarter trend through the year. And if there's any kind of specific things that we need to call out or think about more specifically.
Operator: Thank you. We'll go next now to Conor McNamara at RBC Capital Markets. Hey, guys, thanks for the questions.
Conor McNamara: And I know just one for you. You know, I appreciate the color on the management departures and how that, you know, the timing was, you know, a lot of it was personal related. But can you give us more color on how other non management employee retention has been? Has there been any fallout from some of these departures?
Roop Lakkaraju: No, there hasn't. I mean, you know, obviously in a company of our size and, you know, actually any size, you have a. You have a certain amount of turnover that's natural every year and the, you know, in the kind of the five to 10% range. But no, these departures have not precipitated any, anything else.
Conor McNamara: Okay, thanks for that. And then just, you know, the color you gave on some of these ddPCR partnerships, those are some great announcements. But can you just kind of talk about some of the revenue opportunity for bio rad? And is that, you know, do you see additional equipment placements as a result of these, there's consumable pull through what's kind of the expected ramp of any sales benefit for some of those announced partnerships.
Andy Last: Yes. Yes. Thanks, Connor. This is Andy. So there's slightly different profile for each of these announcements. Allegheny is much more focused on real clinical insight around, you know, minimal residual disease and how best to deploy our technology to, you know, be more effective in that area. So that's really a value creation through insight, learning, clinical, you know, clinical information. The onco site is more tangible in that, you know, this is to generate longer term systems placements and test sales for oncite in particular. And then we will have some beneficial effect from that. But that's kind of a long term strategy. It will have no material impact in the very near term. And then genoscopy, we are the platform they chose to develop on. And as they succeed, and with that platform moving forward, they'll create a consumable and reagent stream for us. And if there's an opportunity which we believe there is, to take that solution beyond the US and into other markets, that creates both test revenue and consumer reagent and system revenue opportunities. None of this is what I would call immediate near term impact, but it's really solid long term strategy.
Conor McNamara: Great. Thanks for that color, Andy. And I don't know if this is your last earnings call, but if so, best of luck in retirement. And Roop, welcome to the team. Thanks guys.
Roop Lakkaraju: Just to be clear, it won't be Andy's last earnings call. We've made sure of that. Thank you. Well, thank you.
Operator: Thank you. [Operator instructions]. And gentlemen, it appears we have no further questions this afternoon. Mister Chung? I'd like to turn things back to you, sir, for any closing comments.
Edward Chung: Yes. Thank you for joining today's call. We will be at the RBC Capital Markets Global Healthcare conference in New York next week, and we'll be back in New York in June for the Jefferies healthcare conference. So, as always, we appreciate your interest and we look forward to connecting soon. Thanks.
Operator: Thank you Mister Chung. We will conclude the Bio-Rad's first quarter earnings results call, again thanks so much all for joining us and we wish you all a great day. Good bye.
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