Investing.com
Published Apr 10, 2024 15:14
KRAKOW,
"We are excited to present our latest advancements in oncology therapeutics at the AACR Annual Meeting this year. Strong preclinical data from our two lead synthetic lethality programs “ PRMT5 and WRN “ are encouraging as we make progress toward the identification of competitive clinical candidates," said Krzysztof Brzózka, Ph.D., Chief Scientific Officer of Ryvu Therapeutics.
Dr. Brzózka added, "We are also proud of our ONCO Prime target discovery platform, which recently received a significant grant from the Polish Agency for Enterprise Development, giving validation and financial support to our innovative drug discovery efforts. At AACR, we present promising data in KRAS-mutant patient-derived colorectal cancer cells, where the ONCO Prime platform has identified promising novel drug targets. With these initial data, we continue to expand the platform's potential to discover novel anticancer targets across various tumor types."
The ONCO Prime target discovery platform aims to identify novel drug targets based on patient-derived primary cell cultures, omics characterization, and functional assays. It already supports preclinical development of Ryvu programs, including PRMT5 and WRN. In
AACR 2024 Poster highlights:
Abstract 'Discovery (NASDAQ:WBD) of novel MTA-cooperative PRMT5 inhibitors as targeted therapeutics for MTAP-deleted cancers.'
Session Name: HDAC and Methyltransferase Inhibitors
Session date and time:
Poster Number: 4598
Abstract 'Discovery of WRN inhibitors as targeted therapy in the treatment of microsatellite unstable (MSI-H) tumors.'
Session Name: Novel Antitumor Agents 4
Session date and time:
Poster Number: 5942
Abstract 'A comprehensive platform for identification of KRAS-specific synthetic lethal targets using patient-derived cells.'
Session Name: New Targets, Technologies, and Drug Delivery Systems
Session date and time:
Poster Number: 4684
Abstract 'Combination JAK1/2 and CDK8/19 inhibition demonstrates enhanced efficacy in myeloproliferative neoplasms.'
Session Name: Targeted, Combination, and Differentiation Therapies
Session date and time:
Poster Number: 7225
Abstract 'MEN1703/SEL24 exhibits promising antitumoral activity in preclinical models of myelofibrosis both as a single agent and combined with ruxolitinib.'
Session Name: Novel Antitumor Agents 2
Session date and time:
Poster Number: 665
Posters are available on https://ryvu.com/our-research/.
About Ryvu Therapeutics
Ryvu Therapeutics is a clinical-stage drug discovery and development company focused on novel small-molecule therapies that address emerging targets in oncology. Internally discovered pipeline candidates use diverse therapeutic mechanisms driven by emerging knowledge of cancer biology, including small molecules directed at kinase, synthetic lethality, and immuno-oncology targets.
Ryvu's most advanced programs include RVU120, a selective CDK8/CDK19 kinase inhibitor with the potential to treat hematological malignancies and solid tumors, currently in Phase II development (i) as a monotherapy for the treatment of patients with relapsed/refractory acute myeloid leukemia (r/r AML) and high-risk myelodysplastic syndromes (HR-MDS) as well as (ii) in combination with venetoclax for the treatment of patients with r/r AML. Another clinical program, SEL24 (MEN1703), is a dual PIM/FLT3 kinase inhibitor licensed to the Menarini Group. Ryvu Therapeutics has signed multiple partnering and licensing deals with global companies, including BioNTech (NASDAQ:BNTX) and Exelixis (NASDAQ:EXEL).
The Company was founded in 2007 and is headquartered in Kraków,
Written By: Investing.com
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